![]() Previous studies confirmed that older age, chronic disease, and D-dimer greater than 1 µg/L were important independent predictors of mortality from COVID-19. Zhou et al reported mortality rates of 0%, 18.2% and 79.2% for patients with moderate, severe and critically ill disease, respectively. The estimated mortality rates in the Li et al study were 1.1% for patients with non-severe disease and 32.5% for patients with severe disease over an average of 32 d. Of 52 critically ill adult patients in the Yang et al study, 32 (61.5%) had died at 28 d. ![]() Feng et al reported that the mortality rates of the moderate, severe and critically ill groups were 6.2%, 12.5% and 49.1%, respectively, in Hubei, and 0%, 0%, and 13.3%, respectively, outside of Hubei. In the latest Chinese Centers for Disease Control (CDC) report that included records from 44672 cases, patients with severe and critical disease accounted for 13.8% and 4.7% of confirmed cases, respectively the crude case fatality rate among critically ill patients was 49%, and the fatality density was 0.325. Several studies have reported the mortality rates of different groups. The main parameters for classification are level of hypoxemia and progression of radiographic presentation. Several studies reported that a number of patients had rapid disease progression and died of acute respiratory distress syndrome and/or multiple organ failure.Īccording to the Chinese management guideline for COVID-19 (versions 1.0 through 7.0), the definition and classification of COVID-19 severity is divided into four levels: mild, moderate, severe and critical. Similar to SARS-CoV, the novel SARS-CoV-2 uses angiotensin converting enzyme II (ACE2) receptors to invade not only type II alveolar cells in the lung but also myocardial cells in the heart, proximal tubule cells in the kidney and other cells in organs with high ACE2 expression levels. the first report of coronavirus disease 2019 (COVID-19) in Wuhan, China, in December 2019, this highly infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly throughout the world, posing a serious threat to global health. 1 Dahua Road, Dong Dan, Beijing 100730, China. 201920202102.Ĭorresponding author: Huan Xi, MD, Doctor, Department of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. Supported by Disciplines Construction Project of Peking Union Medical College, No. Author contributions: Chu X, Zhang GF, Zheng YK, Zhong YG, Wen L, Zeng P, Fu CY, Tong XL, Long YF, Li J, Liu YL and Chang ZG created the database and collected the data Chu X, Zhang GF, Chang ZG and Xi H performed the study and wrote the manuscript Chu X and Zhang GF performed the statistical analysis and interpreted the data all authors providing critical feedback and edits to subsequent revisions Chu X and Zhang GF contributed equally to this study Chang ZG and Xi H are the guarantors, and considered as co-corresponding authors Chang ZG and Xi H attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted.
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